Consanguinity and Polygenic Diseases: A Model for Antibody Deficiencies
نویسندگان
چکیده
منابع مشابه
Consanguinity and polygenic diseases: a model for antibody deficiencies.
Primary immunodeficiencies represent a heterogeneous group of disorders of the immune system, predisposing to various types of infections. Among them, common variable immunodeficiency is the most common symptomatic antibody deficiency. It includes several different forms characterized by defects in the terminal stage of B lymphocyte differentiation, leading to markedly reduced immunoglobulin se...
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Polygenic diseases are caused by the joint contribution of a number of independently acting or interacting polymorphic genes; the individual contribution of each gene may be small or even unnoticeable. The carriage of certain combinations of genes can determine the occurrence of clinically heterogeneous forms of the disease and treatment efficacy. This review describes the approaches used in a ...
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There is little information on inbreeding during the critical early years of human existence. However, given the small founding group sizes and restricted mate choices it seems inevitable that intrafamilial reproduction occurred and the resultant levels of inbreeding would have been substantial. Currently, couples related as second cousins or closer (F ≥ 0.0156) and their progeny account for an...
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15 صفحه اولGenetic bases for common polygenic diseases.
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2014
ISSN: 1423-0062,0001-5652
DOI: 10.1159/000362364